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KMID : 0854720120320040203
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 4 p.203 ~ p.206
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Long-Lived Plasma Cell
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Lee Ju-Suk
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Abstract
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Plasma cells are usually considered short-lived plasma cells. This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults. Elimination of long-lived plasma cells that secrete specific
immunoglobulin E may provide a cure in allergic patients. The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.
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KEYWORD
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Long-lived plasma cell, Plasma cells, Autoimmunity, Hypersensitivity
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